Core Informatics’ SLAS 2016 Review

Emerging Technologies and Informatics

Did you join us at SLAS 2016? It was a whirlwind of single cell analysis, CRISPR/Cas9 genetic screening, 3D cell culture, collaboration in informatics, and so much more. Not to mention an exhibition hall jam packed with cutting edge technology created to enable your bench work from experimental design through data analysis.

If your lab is working on new and innovative ways to run a more efficient screen you may have found your answers here. Many of the talks and conversations focused on more relevant models for cell based screening and maximizing efficiency by leveraging new laboratory automation platforms. Ultimately, the focus was on an inside view into how different labs are approaching the same challenging questions.

LIMS Systems Applications for Changing Analysis

Cell culture has evolved into more relevant models, including 3D culture on microcarriers, including magnetic beads, and droplet formation. Comparison of 2D versus 3D cell culture in small molecule screening has shown a decrease in false hits and is compatible with standard plate readers.

While some readers of this post are creating groups of cells functioning together, others are looking at cells a little differently. Single cell analysis continues to be a leader in determining tissue heterogeneity and is growing in its use in personalized medicine. New software companies have burgeoned as well, enabling easier analysis and visualization of more complex data. A software platform with the ability to handle a variety of applications is essential for these technologies. As you determine the need to add new workflows to your LIMS system, new applications should be available to handle your plans. These will allow you to configure your LIMS system to fit the needs of your labs in a short amount of time – as opposed to a long process of custom coding which would only serve to delay your research.

CRISPR/Cas9 Seminar

But let’s take it one step further. Is your lab interested in finding new targets, changing the expression of a previously identified target, or creating model systems for genetic disease? If so, we likely saw you in a CRISPR/Cas9 seminar. This new technology has gained a solid following with those of us looking to leverage gene editing. Surpassing Zinc finger and TALEN technology because of its ease of use and, in some cases, RNAi screening because of its ability to completely knockout expression, CRISPR is emerging as a major player in biopharma research.

LIMS System Solutions

But with all these new and exciting ways to gain information comes the challenge of managing samples, experiments, protocols, requests and data. Luckily, Core Informatics was on hand at SLAS 2016 to keep abreast of all the hot science right alongside you. We sat in the seminars, participated in the Special Interest Groups, and chatted with the vendors. We are scientists looking to make life a little easier in the lab and are working to manage your samples, workflows, and data. When it comes to data analysis, we strive to partner with the best of breed for analysis software, from Next Gen Sequencing solutions to flow cytometry, plate reader data, and everything in between. We continuously search for the latest instrumentation, consumables, and technology to ensure that we understand what you do at the bench – allowing us to create software solutions that fit your innovative workflows.

To learn more about our software systems and how they work across our lab management platform, read our Platform for Science white paper or our Next Generation Sequencing white paper.

Heather Adinolfi is the Biopharma Application Manager at Core Informatics. She holds a Masters degree in Molecular and Cell Biology and 8+ years’ experience in genomics and cell biology laboratories. Most recently, Heather was a member of the Leads Discovery department at Bristol-Myers Squibb where she maintained and developed new cellular reagents for high throughput screening initiatives.