Launch14 Review – Walter Reed Army Institute of Research

The Experimental Therapeutics (ET)branch at the Walter Reed Army Institute of Research has nearly half a century history of drug development. Fundamental components of ET‰’s successful ‰bench-to-bedside‰ product development to combat infectious disease includea physical repository with over one million compounds and associated database of compound-related information. Prior to 2013, WRAIR had been utilizing a homegrown database (CIS) for managing compound-related information. Advances in commercial off the shelf (COTS) technology capable of increasing our efficiency and effectiveness led to the decision to migrate away from the CIS. In June, 2013 the Core LIMS officially replaced the CIS as ET‰’s COTS-based LIMS to support drug development.

The Core LIMS is now used in all aspects of ET‰’s drug development mission to include:

1) Compound registration (>5,000 annually); inventory (>700,000 samples)

2) Shipments (>15,000 annually)

3) Data associated with chemical & biological testing (>20 active test systems)

The transition from CIS to Core LIMS was challenging due to the high level of complexity associated with each of these laboratory functions. A number of these challenges included areas of sample registration, testing requests, data uploads, database search & report generation and historical record transition. Importantly, all of these challenges were addressed through additional instruction provided to the system administrators and end users, changes in business practices and/or specific Core LIMS configuration edits. Efforts by Core Informatics have greatly influenced positive outcomes by providing dedicated support throughout the transition. The Core LIMS administration group, including ET, Core Informatics and repository personnel, continues to work jointly to provide user-friendly solutions associated with data input, inventory management, infrastructure, system security, and overall implementation of the Core LIMS into the drug development process.

Inventory data management including structure, synthetic batch and containers) are part of the Core LIMS implementation Inventory data management including structure, synthetic batch and containers) are part of the Core LIMS implementation

All chemical and biological data is captured and cataloged with easy access to researchers and management All chemical and biological data is captured and cataloged with easy access to researchers and management

Full compound registry and LIMS workflows are integrated for comprehensive information management Full compound registry and LIMS workflows are integrated for comprehensive information management

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