Biopharma

The Role of ADME & Toxicology Studies in Drug Discovery & Development

What do ADMET studies provide to drug developers? A critical piece in drug discovery and development is conducting DMPK (Drug Metabolism and Pharmacokinetics) studies, often referred to as ADMET (Absorption, Distribution, Metabolism, Elimination, Toxicity) studies. These studies help to determine the viability of a drug candidate by answering these key questions: Absorption – How much…

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Connecting the Microbial Ecosystem

The Microbiome – A Growing Field Within Research and Development An emerging field of research across multiple industries is the study of the microbiome. Understanding the components of the microbiome, such as bacteria, viruses, and fungi, impacts food production, animal health, environmental restoration and, perhaps most importantly, human health. We now understand that the human…

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WRIB 2018 – A Workshop on Recent Issues in Bioanalysis

A Collaborative Workshop to Discuss Bioanalysis The Workshop on Recent Issues in Bioanalysis (WRIB) gathers industry and regulatory leaders from around the world, to discuss challenges in the discovery and development of bioanalytical, biomarker, and immunogenicity assays. The FDA, Regeneron, Pfizer, MHRA, Sanofi, EMA, Bristol-Myers Squibb, and Biogen were just some of the presenters from this…

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Antibody Profiling

Assays to Predict Developability Antibody therapies are not novel. The first FDA approval and commercialization for an antibody therapeutic was in 1986 for Orthoclone OKT3, which was approved for prevention of kidney transplant rejection (Ecker et al. 2015). As of today, there are 78 monoclonal antibody treatments on the market to treat a wide variety…

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New Apps for Small Molecule Analysis

Capture, analyze, and report on analytical data from a variety of instruments Analyzing registered small molecules for composition and purity is an important step in the small molecule drug development workflow.  We’ve created a few new apps that are focused on helping scientists improve and simplify the analysis process. New Small Molecule Applications We’ve added…

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Overcome Early Stage Bioprocess Data Management Challenges

Learn how a unified informatics platform can help USP and DSP teams to collaborate and optimize processes Creating a successful therapeutic agent is the end goal of bioprocess engineering. This process involves a careful understanding of the most desirable conditions for production, and then reproducing these conditions during scale-up. Frequently this data is stored across…

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Manage, Track and Optimize Bioprocess Workflows

New Bioprocess Applications Available for the Platform for Science Paying attention to your data and reacting to what it is telling you is essential for optimizing both upstream and downstream bioprocess workflows. In fact, it’s the key to helping your plant or lab operate to its full potential. New Bioprocess Applications A new set of…

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New Apps for Animal Management and In Vivo Studies

Alleviating Data Management Pain Points in Animal Studies Animal studies are foundational in research. They allow us to determine efficacy and toxicity, and give us close approximations for human models in drug metabolism, cognitive function, and everything in between. The execution of these types of studies is often spread throughout many groups within an organization,…

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The Magic Behind Laboratory Success

A Trick to Lab Process Improvement Do you believe in magic?  A quick survey of scientists in the Core office unearthed stories of singing the “right” songs, assays successful in one person’s “magic” hands, or the “cursed” centrifuge that would inevitably produce disappointing results.  These seemingly “magic” results often give scientists pause and suggest a…

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New Protein Purification and Analysis Applications

New Apps Enhance Sample Tracking and Analysis Capabilities New applications for protein purification and analysis are now available for the Platform for Science. These new apps allow scientists to track samples, define assays and track results for a variety of protein purification experiment types. The applications are designed to enhance the existing Biologics Solution available…

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